HSV-1 nucleocapsid egress mediated by UL31 in association with UL34 is impeded by cellular transmembrane protein 140
نویسندگان
چکیده
منابع مشابه
Homologues of HSV-1 nuclear egress factor UL34 are potential phosphoinositide-binding proteins.
During the herpesvirus replication cycle, viral transcription, DNA replication, formation of capsids and DNA packaging occur in the nucleus. The subsequent nuclear egress of newly synthesized nucleocapsids is performed by budding of the inner leaflet of the nuclear membrane, which creates the primary envelope. Although products of two genes conserved throughout the Herpesviridae family (HSV-1 U...
متن کاملCommunication Homologues of HSV-1 nuclear egress factor UL34 are potential phosphoinositide-binding proteins
During the herpesvirus replication cycle, viral transcription, DNA replication, formation of capsids and DNA packaging occur in the nucleus. The subsequent nuclear egress of newly synthesized nucleocapsids is performed by budding of the inner leaflet of the nuclear membrane, which creates the primary envelope. Although products of two genes conserved throughout the Herpesviridae family (HSV-1 U...
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32 To clarify the function(s) of the herpes simplex virus 1 (HSV-1) major virion 33 structural protein UL47 (also designated VP13/14), we screened cells overexpressing UL47 34 for UL47-binding cellular proteins. Tandem affinity purification of transiently expressed 35 UL47 coupled with mass spectrometry-based proteomics technology and subsequent analyses 36 showed that UL47 interacted with cell...
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The interaction between two regulatory proteins plays a crucial role in the control of several biological events, including gene transcription. In this report, we demonstrate that the interaction between the cellular sequence-specific single-stranded DNA binding protein Puralpha and the HIV type 1 (HIV-1) Tat protein is mediated by specific ribonucleic acids. The region of Tat that is important...
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Herpes simplex virus type-1 (HSV-1) is a neurotropic pathogen of humans that establishes latent infection in the sensory ganglia innervating the site of primary infection. A number of genes control HSV-1 pathogenicity and latency. Open reading frame P (ORF P) is one of these genes that might have a role in latency and pathogenesis. A complication in the analysis of the role of ORF P in the HSV-...
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ژورنال
عنوان ژورنال: Virology
سال: 2014
ISSN: 0042-6822
DOI: 10.1016/j.virol.2014.06.034